Additional file 3.

Figure S1. Simulation aimed to demonstrate that Italy and Spain are sufficiently different in terms of haplotype sharing, therefore, supporting the results of admixture analysis. First, two databases were considered jointly, the Spanish (n = 1467) and the Italian database (n = 1667) (see Additional file 1: Table S1, and text for more information on the databases). From this global database (n = 3134), two samples of sizes 1467 and 1667 each were taken at random without replacement 10,000 times. The distribution represents the number of identical shared haplotypes (horizontal axis) and their counts (vertical axis) between the 10,000 pairs of random samples. The red line indicates the observed number of haplotypes shared between the Italian and the Spanish database (n = 134; see also Figure 2).

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Catelli et al. BMC Genetics 2011 12:77   doi:10.1186/1471-2156-12-77