Table 3

Relationship between IL12B 3' UTR genotypes and susceptibility to SMA

IL-12B 3' UTR Genotype

OR

95% CI

P

OR

95% CI

P

SMA (Hb<5.0 g/dL)

SMA (Hb<6.0 g/dL)

AA

reference

reference

AC

1.268

0.799-2.011

0.314

1.410

0.953-2.098

0.086

CC

1.512

0.870-2.629

0.142

1.674

1.006-2.673

0.047

CC vs. AC + AA

1.335

0.816-2.185

0.249

1.370

0.880-2.133

0.826

AA vs. AC+CC

1.346

0.881-2.058

0.170

1.479

1.031-2.123

0.034

Parasitaemic children (n = 544) were categorized according to the WHO SMA definition [i.e., Hb<5.0 g/dL, with any density parasitaemia [26]] and the age- and geographically-appropriate definition of SMA [(Hb<6.0 g/dL, with any density parasitaemia [4]]. Odds Ratio (OR) and 95% confidence interval (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1, bacteremia, and sickle-cell trait (HbAS) status.

Ong'echa et al. BMC Genetics 2011 12:69   doi:10.1186/1471-2156-12-69