Table 2

Distribution of IL12B 3' UTR genotypes in children with P. falciparum malaria

IL12B 3' UTR Genotypes

Non-SMA

SMA

Pa


No. of participants, n

304

240

AA

132 (43.4)

82 (34.2)

AC

123 (40.5)

104 (43.3)

0.048

CC

49 (16.1)

54 (22.5)

P(A) = 0.64

P(A) = 0.56


Data are presented as proportion of individuals [n (%)] within non-SMA and SMA groups. Children with P. falciparum malaria (n = 544) were categorized according to SMA status based on age- and geographically-appropriate Hb concentrations [i.e., Hb<6.0 g/dL, with any density parasitaemia) [4]] and non-SMA (Hb≥6.0 g/dL, with any density parasitaemia). aStatistical significance determined by Chi-square analysis. The overall distribution of genotypes between the non-SMA and SMA groups was statistically significant (χ2 test, P = 0.048).

Ong'echa et al. BMC Genetics 2011 12:69   doi:10.1186/1471-2156-12-69

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