Table 3

Comparative positional analysis of identified QTL with serum lipid QTL in humans and mice and the putative candidate genes located on the QTL regions

SSC

Traits

POS (cM)

PCB at peak

HCHR

QTL in human

HCBP

Putative candidate genes

Mouse strain

QTL mouse peak


1

CT*

80

1q1.3 - 1.4

18q21

15q21-22

CT

18q21 [51]

LIPC [52], LIPG [53], ACAA2 [54], STARD6 [55]

(B6 × C3H) F2

(B6 × DBA/2) F2

(B6 × CAST/2) F2

(B6 × C3H) F2

18-40cM

18-46cM

18-47cM

18-48cM

1

HDL/LDL**

87

1q1.5-1.6

HDL

15q21 [56], 15q22 [57]

(B6 × 129) F2

2-90 cM

1

LDL***

82

1q1.3 - 1.4

LDL-ApoB1

18q21.32 [58]

2

TG

205

2q2.8-2.9

5q23-31

TG

5 q21.3 -q32 [59]

STARD4 [60]

2

HDL*#

118

2p1.2- 2q1.2

11q13

HDL

11q12-13 [31]

CILP, PBX4

(MRL × SJL) F2

(B6 × C3H) F2

7-10 cM

7-19 cM

3

HDL*

0

3p1.5-p1.4

7q11

HDL

TC

7q11.23 [61]

7q11.23 [62]

FABP1

(NZB × SM) F2

NZO × (SJL × NZO)

(B6 × CAST) F2

5-61.cM

5-69cM

5-72 CM

4

HDL/LDL*

58

4q1.4-1.5

1q22-25

HDL

1q21-23 [63]

1q23-25 [64];

1q24 [65], 1q25 [66]

CYP7A1[67,68];

FABP5[69]

(B6 × NZB11) F2

1-91 CM

6

CT*

99

6q2.3 - 2.4

1p36.3-36.1

LDL

1q36.31 [63]

1q36.13 [70]

NR1H2

WWOX [71] LDLRAP1

6

TG*

66

6q1.1 - 2.1

19q13

LDL,

TG

19 q12 39 cM [72]

19q13.31 [51], [73]

APOE [74]; ANGPTL3

7

CT, LDL*

70

7q1.4-71.5

15q24-28

LDL

15q26.1 [51]

STARD5

11

TG*#

28

11p1.1 -1.2

13q12 -24

TG and HDL

13q13 [75]

12

CT**

36

12p1.3-q1.2

17q21-25

CT/HDL

17q24 [76]

WIPI1,

12

LDL*

38

LDL

17q24.2 [65]; 17q25.3 [77]

THRA PEMT

13

LDL*

97

13q3.3 -3.5

3p31-21

LDL

3p25 [72]

PCYT1A [78]; B4GALT4 [79]

(C56BL/6JxDBA/2J)

3-27cM [80]

16

HDL*

81

16q1.4-2.1

5p14 -12

HDL

5p13.3 [81]

5p15.13 [82]

(PERAxDBA/2) F2

(PERAxI) F2

11-28 cM

11-28 cM

16

HDL/LDL*

47

16q1.3-1.4

5p14 -12

LDL

5p15.33 [64]

17

TG*#

72

17q2.2-2.3

13q13

TG and HDL

13q13 [75]

ACSS, PLTP


PCB, pig cytogenetic band; HCHR, human chromosome homologous regions; HCBP, human cytogenetic band.

Significance: Significance of the QTL: * significant on a chromosome-wide level with P < 0.05; ** significant on a experiment-wide level with P < 0.05; *** significant on a experiment-wide level with P < 0.01. Human homologous regions of the pig QTL were identified with the pig QTL database. # QTL with imprinting effect.

Uddin et al. BMC Genetics 2011 12:62   doi:10.1186/1471-2156-12-62

Open Data