Table 1

Allelic Frequencies FADS Gene Cluster Variants Differ by Race.

SNP

Allele associated with increased LC-PUFAS

GeneSTARa

DHSb

HapMapc

[ancestral/derived allele]d

Position

African American

European American

African American

European American

CEU

ASW

YRI


rs174537 [T/G]

61309256

G

0.91

0.67

0.89

0.65

0.66

0.92

0.99

rs102275 [A/G]

61314379

A

0.37

0.67

0.33

0.64

0.65

0.39

0.31

rs174546 [T/C]

61326406

C

0.92

0.67

0.91

0.65

0.66

0.92

0.99

rs174556 [C/T]

61337211

C

0.92

0.71

0.91

0.68

0.7

0.93

0.99

rs1535 [G/A]

61354548

A

0.86

0.67

0.83

0.64

0.66

0.88

0.88

rs174576 [A/C]

61360086

C

0.74

0.66

0.7

0.64

0.66

0.71

0.72

rs174579 [C/T]

61362189

C

0.95

0.79

0.92

0.79

0.77

0.95

0.99


Frequencies of the allelic variant associated with higher levels of LC-PUFAs at seven SNPs mapping to the FADS gene cluster in the family-based GeneSTAR study, subjects from the DHS study, and the publicly availably HapMap project, illustrating higher frequencies in individuals of African ancestry.

aAllele frequency estimates were obtained from in a defined set of all founders from the GeneSTAR families (339 African American founders and 484 European American founders).

bFrequency based on 33 independent African American and 89 independent European American subjects from the DHS.

cData on the Utah residents with Northern and Western European ancestry from the CEPH collection (CEU), Yoruban in Ibadan, Nigeria (YRI) and African ancestry in Southwestern USA (ASW) from the publicly available International HapMap Project (www.hapmap.org webcite).

dDefinition of ancestral/derived allele based on dbSNP definitions (http://www.ncbi.nlm.nih.gov/projects/SNP/ webcite).

Mathias et al. BMC Genetics 2011 12:50   doi:10.1186/1471-2156-12-50

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