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The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans

Rasika A Mathias12*, Susan Sergeant34, Ingo Ruczinski5, Dara G Torgerson6, Christina E Hugenschmidt7, Meghan Kubala1, Dhananjay Vaidya1, Bhoom Suktitipat1, Julie T Ziegler8, Priscilla Ivester49, Douglas Case8, Lisa R Yanek1, Barry I Freedman10, Megan E Rudock11, Kathleen C Barnes2, Carl D Langefeld8, Lewis C Becker1, Donald W Bowden1137, Diane M Becker1 and Floyd H Chilton49

Author Affiliations

1 Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, 1830 E. Monument St., Baltimore, MD 21224, USA

2 Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 1830 E. Monument St., Baltimore, MD 21224, USA

3 Department of Biochemistry, Medical Center Blvd., Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA

4 Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention, Medical Center Blvd., Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA

5 Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21224, USA

6 Department of Human Genetics, 920 E. 58th St., University of Chicago, Chicago, IL 60637, USA

7 Center for Diabetes Research, Wake Forest University Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157, USA

8 Division of Public Health Sciences, Department of Biostatistical Sciences, Medical Center Blvd., Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA

9 Department of Physiology/Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157, USA

10 Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157, USA

11 Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd., Winston-Salem, NC 27157, USA

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BMC Genetics 2011, 12:50  doi:10.1186/1471-2156-12-50

Published: 20 May 2011

Additional files

Additional File 1:

Conservation of FADS gene cluster presented as percentage homology for protein and DNA between humans and other species as reported in Homologene (http://www.ncbi.nlm.nih.gov/homologene webcite) revealing considerable conservation in range of species including chicken for FADS1(~737%) and FADS2 (~75%), and zebra fish for FADS2 (~65%).

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Additional File 2:

Allelic Effect on Trait Distribution in the Two Ancestry Groups. Allelic effect on trait distributions of age- and gender-adjusted ω6 PUFAs (AA and DGLA) and FADS1 enzymatic efficiency (AA/DGLA) was examined in the African Americans and European Americans from the GeneSTAR Study

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