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Open Access Methodology article

Combining an Evolution-guided Clustering Algorithm and Haplotype-based LRT in Family Association Studies

Mei-Hsien Lee1, Jung-Ying Tzeng2, Su-Yun Huang3 and Chuhsing Kate Hsiao456*

Author Affiliations

1 Department of Mathematics and Computer Science Education, Taipei Municipal University of Education, Taipei 10048, Taiwan

2 Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695, USA

3 Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan

4 Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10055, Taiwan

5 Bioinformatics and Biostatistics Core, NTU Center for Genomic Medicine, National Taiwan University, Taipei 10055, Taiwan

6 Research Center for Gene, Environment, and Human Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan

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BMC Genetics 2011, 12:48  doi:10.1186/1471-2156-12-48

Published: 19 May 2011

Additional files

Additional file 1:

Derivation of haplotype frequency estimates and haplotype explanation set for each family based on genotype data.

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Open Data

Additional file 2:

The complete plot of LD for all tag SNPs.

Format: PDF Size: 453KB Download file

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Open Data

Additional file 3:

Derivation of P(A|D).

Format: PDF Size: 13KB Download file

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Open Data