Table 3

Number of significant interactions in the subpopulations in the Supine model

Partition:

model with covariates

Supine model without covariates


Trait:

Systolic

Diastolic

Systolic

Diastolic


Subpopulations

No cases

Interactions

Fraction

Interactions

Fraction

No cases

Interactions

Fraction

Interactions

Fraction


1

39

307

32,49%

307

32,49%

27

331

35,03%

306

32,38%


2

111

318

33,65%

316

33,44%

113

325

34,39%

325

34,39%


3

259

298

31,53%

294

31,11%

625

323

34,18%

335

35,45%


4

33

230

24,34%

334

35,34%

104

338

35,77%

338

35,77%


5

189

257

27,20%

257

27,20%

1

0

0,00%

0

0,00%


6

301

321

33,97%

310

32,80%

30

320

33,86%

320

33,86%


7

132

306

32,38%

307

32,49%

23

262

27,72%

332

35,13%


8

89

238

25,19%

238

25,19%

89

304

32,17%

305

32,28%


9

237

275

29,10%

276

29,21%

332

231

24,44%

238

25,19%


10

141

334

35,34%

337

35,66%

279

295

31,22%

295

31,22%


11

163

295

31,22%

302

31,96%

7

0

0,00%

0

0,00%


12

40

336

35,56%

336

35,56%

544

226

23,92%

232

24,55%


13

166

307

32,49%

306

32,38%

73

285

30,16%

285

30,16% 32,28%


14

21

174

18,41%

148

15,66%

19

159

16,83%

305



Sum

1.921

3.996

4.068

2.266

3.399

3.616


Average

285,43

30,20%

290,57

30,75%

242,79

25,69%

258,29

27,33%


Variance

2.115

2.498

13.074

13.012


Average Total

30,20%

30,75%

25,69%

27,33%


Minimum

21

174

18,41%

148

15,66%

1

0

0,00%

0

0,00%


Maximum

301

336

35,56%

337

35,66%

625

338

35,77%

338

35,77%



Systolic versus diatolic blood pressureb

Number of interactions

Number of interactions


p-value

0,78

0,72



Supine model with and without covariatesc


Systolic

Diastolic


F-test

p-value

0,0024

0,0055



Number of total interactions detected

Full model

Model without co-variates


Interactions

Fraction

Interactions

Fraction


Systolic

676

68,28%

695

70,20%


Diastolic

681

68,79%

695

70,20%


a The fraction is calculated as the number of significant interactions detected realtive to the maximal number of interaction possible

b Test of difference in number of interactions between diastolic and systolic blood pressures

c Test of the number of significant interactions in the two models. The number of interactions in the model with covariates (the fulle model)

is significant higher than in the resticted model without covariates.

Fenger et al. BMC Genetics 2011 12:44   doi:10.1186/1471-2156-12-44

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