The figure illustrates the simplified blood pressure model. The centre of the model is the latent "Vascular bed", which is in quotation mark as it represent a latent structure harboring all kinds of metabolic, physiologic and genetic processes in the arterial vessels. The physiological state of the vascular bed govern the diastolic and systolic blood pressures, which are the indicators in the model. The physiological state of the arterial vessels are influenced by several covariates as indicated in the figure. The covariates Apolipoproteins, Lipids, Antropometric, and Inflammatory covers several items each, but are not shown separately (see the text for details). Insulin and glucose is the variables used to calculate insulin resistance (HOMAres), but is not shown here as the measure is partly an intrinsic parameter in the vascular cells as well as many other tissues.
Fenger et al. BMC Genetics 2011 12:44 doi:10.1186/1471-2156-12-44