Table 2

Associations of the SNPs and haplotypes in ESR2, EAAT2, BDNF, GABRA6, DRD1, OXTR and 5-HTR2C genes with sow maternal infanticide behavior

gene

Polymorphism

Allele or Haplotype1

Allele or Haplotype Frequency

Individuals of maternal infanticide


T

UT

DF

LRS

P


ESR2 (HM754215)

g.1170 G > A

A

0.341

40

24

1

4.043

0.044*

G

0.659

24

40

g. 1202G > A

A

0.501

52

29

1

6.623

0.010*

G

0.499

29

52

g. 2681G > T

G

0.534

50

28

1

6.290

0.012*

T

0.466

28

50

-

GGT

0.457

10

30

2

5.993

0.049*

-

GAG

0.143

7

2

-

AAG

0.361

23

8

EAAT2 (HM754214)

g. 233G > A

A

0.693

43

20

1

8.594

0.003*

G

0.307

20

43

g.489G > A

A

0.235

19

28

1

1.734

0.188

G

0.765

28

19

g.1028G > A

A

0.238

20

29

1

1.662

0.197

G

0.762

29

20

-

AGG

0.652

29

6

2

10.124

0.007*

-

GAA

0.278

4

20

-

GGG

0.070

2

11

BDNF (HM754212)

g.612C > A

C

0.748

27

19

1

1.391

0.238

A

0.252

19

27

g.2723G > A

G

0.513

37

45

1

0.781

0.377

A

0.487

45

37

g.3481A > G

A

0.594

33

31

1

0.063

0.803

G

0.406

31

33

-

AAA

0.245

9

12

3

3.762

0.288

-

CAA

0.241

19

8

-

CGA

0.108

4

9

-

CGG

0.394

16

19

OXTR (HM754217)

g.509G > A

G

0.811

21

15

1

1.000

0.316

A

0.189

15

21

g.1211T > C

T

0.487

26

35

1

1.333

0.248

C

0.513

35

26

g.2271C > T

C

0.836

13

21

1

1.900

0.168

T

0.164

21

13

-

ACC

0.193

15

8

3

2.350

0.503

-

GTT

0.146

10

16

-

GTC

0.357

15

18

-

GCC

0.304

21

19

DRD1 (HM754213)

g.1013C > G > T

C

0.500

47

35

2

9.485

0.009*

G

0.424

28

46

T

0.076

7

1

g.1655C > T

C

0.795

26

17

1

1.898

0.168

T

0.205

17

26

-

GT

0.205

5

17

3

10.068

0.018*

-

TC

0.066

7

1

-

CC

0.511

30

18

-

GC

0.218

6

12

GABRA6 (HM754216)

g. 176C > T

T

0.266

30

37

1

0.546

0.460

C

0.734

37

30

g.444A > T

A

0.576

29

35

1

0.563

0.453

T

0.424

35

29

g.1520G > A

T

0.590

29

34

1

0.397

0.529

G

0.410

34

29

-

TTG

0.521

15

18

2

4.510

0.123

-

CAT

0.257

15

17

-

CTG

0.132

11

3

5-HTR2C (HM754211)

g.675C > T

A

0.606

15

7

1

2.909

0.088

G

0.394

7

15


Note: T: Transmission; UT: Untransmission; LRS: likelihood ratio statistic. The likelihood ratio statistic is minus twice the difference in log-likelihoods; P: P value from the overall test of association; DF: degree of freedom;

*: significant in statistics

1. Rare haplotypes were excluded from association study.

Chen et al. BMC Genetics 2011 12:24   doi:10.1186/1471-2156-12-24

Open Data