Table 1

The eight candidate bovine imprinted genes analysed in this study

Gene

Ensembl gene ID

BTA1

Gene function2

Imprinting status in cattle

Additional species in which gene is imprinted/Preferentially-expressed allele3


CALCR

ENSBTAG00000017458

4

Involved in regulating calcium homeostasis; involved in osteoclast-mediated bone resorption

No data available

Human; Mouse/

Maternal expression in both species


GRB10

ENSBTAG00000017086

4

Involved in signal transduction; interacts with insulin receptors and insulin-like growth factor receptors

Tested but unconfirmed4

Human; Mouse; Sheep/

Isoform-dependent maternal and paternal expression


ZNF215

ENSBTAG00000003638

15

Putative role in transcriptional regulation

No data available

Human/

Maternal expression but biallelic expression has been reported in some tissues


PEG3

ENSBTAG00000023338

18

Role in cellular apoptosis

Imprinted, paternal expression5

Human; Mouse; Sheep/

Paternal expression in all species


ZIM2

ENSBTAG00000011664

18

Putative role in transcriptional regulation

Biallelic expression6

Human; Mouse/

Paternal expression in humans. Tissue-specific maternal and biallelic expression has been reported in mouse


RASGRF1

ENSBTAG00000019940

21

Signal transduction and cellular proliferation

No data available

Mouse/

Paternal expression


PHLDA2

ENSBTAG00000031194

29

Tumour suppressor gene

No data available

Human; Mouse; Pig/

Maternal expression


TSPAN32

ENSBTAG00000002702

29

Possible tumour-suppressor functions

No data available

Mouse/

Developmental-stage specific maternal expression


Information regarding the expressed allele for all eight genes is based on the patterns of imprinting in mouse and human and, where possible, cattle, sheep and pigs. The chromosomal location of each gene was obtained from the ENSEMBL database (http://www.ensembl.org webcite) and are based on Build 4.0, Ensembl release 59, of the B. taurus genome sequence (August 2010). The ENSEMBL database gene identity (ID) for each gene is given.

1 B. taurus chromosome number

2 Data taken from the GeneCards Version 3 database [64]; [http://www.genecards.org webcite]

3 Data taken from the Catalogue of Parent-of-Origin Effects database [16] and the Geneimprint database [14]

4 Tveden-Nyborg et al. [34]

5 Khatib et al. [35]

6 Kim et al. [32]; Kim et al. [33]

Magee et al. BMC Genetics 2010 11:93   doi:10.1186/1471-2156-11-93

Open Data