Table 4

NAT2 haplotypes frequency in Brazilian ethnic groups.
Haplotype SNPs (HWpval) Haplotypes (n)
C.N.

G191A

(0.348)

C481T

(0.613)

G590A

(1.0)

A803G

(0.303)

G857A

(0.524)

Total Afro-Brazilians Whites Amerindians
A (NAT2*4) G C G A G 45 33 9 6
B (NAT2*C) G T G G G 35 6 4 3
C* (NAT2*6A/*6B) G C A A G 23 3 1 7
D (NAT2*11A/*11B) G T G A G 23 5 2 2
E (NAT2*6I/6J) G C A A A 11 2 1 -
F (NAT2*7A/*7B) G C G A A 9 1 3 -
G (NAT2*14A/*14B/*14H) A C G A G 8 1 1 -
H (NAT2*12) G C G G G 6 1 1 -
I** (NAT2*6E) G T A A G 5 - - 3
J (n.ds.) G T G A A 4 1 - 0
K (NAT2*12C+857A) G T G G A 4 1 - 1
L (NAT2*14C/*14I) A T G A G 3 - 1 -
Slow Acetylator Haplotype A N A N N 50 29+ 6+ 11+

HWpval: Hardy-Weinberg equilibrium p-value for the whole sample. * and ** significant difference in frequency between Amerindians and Afro-Brazilians (χ2: 6.517; p = 0.0107 and χ2: 5.539; p = 0.0186, respectively). C, E, G, I and L are slow acetylator haplotypes and are indicated in bold. '-': Absent or with frequency < 1%. 'N': any nucleotide. '+': haplotypes with frequencies < 1% are included. C.N.: Consensus Human Arylamine N-Acetyltransferase Gene Nomenclature -http://louisville.edu/medschool/pharmacology/consensus-human-arylamine-n-acetyltransferase-gene-nomenclature webcite; (n.d.s): SNP combination not described

Talbot et al.

Talbot et al. BMC Genetics 2010 11:87   doi:10.1186/1471-2156-11-87

Open Data