Table 2

Genotypic and allelic frequency of NAT2 gene in different ethnic groups.

NAT2

SNP

Total Afro-Brazilians χ2 p1 Whites χ2 p2 Amerindians χ2 p3
G191A
GG 158 104 23 27
GA 22 20 1.075 0.5842 4 1.781 0.4104 3 1.207 0.547
AA 3 1 1 0
G 28 228 0.202 0.6593 50 1.322 0.2471 57 0.942 0.3061
A 338 22 6 3
C481T
CC 72 41 11 12
CT 79 60 2.565 0.2774 15 4.836 0.089 10 2.36 0.3073
TT 31 23 2 8
C 223 142 1.466 0.2221 37 1.079 0.2982 34 0.007 0.9338
T 141 106 19 26
G590A
GG 92 77 19 10
GA 67 46 1.298 0.5224 8 4.312 0.1158 14 9.943 0.0069b
AA 24 2 1 6
G 251 200 0.005 0.9405 46 4.661 0.0288a 34 8.4 0.0053c
A 115 50 10 26
A803G
AA 107 64 15 17
AG 73 61 3.662 0.1603 11 1.333 0.5135 12 0.954 0.6207
GG 3 0 2 1
A 287 189 1.686 0.1836 41 0.117 0.7316 46 0.834 0.3538
G 79 61 15 14
G857A
GG 129 86 17 24
GA 51 33 0.986 0.6108 10 3.391 0.1835 6 3.244 0.1975
AA 3 6 1 0
G 309 205 0.419 0.524 44 2.750 0.0964 54 2.013 0.1373
A 57 45 12 6

p: Genotype and allelic p-value for each marker, respectively. p1, p2 and p3: Association between Afro-Brazilians × Whites; Whites × Amerindians and Amerindians × Afro-Brazilians, respectively. a, b and c: p-value adjusted (103 permutations) = 0.06494, 0.006993 and 0.004995, respectively. χ2: Chi-square tests. Significant association is indicated in bold.

Talbot et al.

Talbot et al. BMC Genetics 2010 11:87   doi:10.1186/1471-2156-11-87

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