Table 1 

Improvement of haplotype modelling from including adjacent interactions. 

Density 
Number of marker SNP sets with adjacent interactions included 
Number (proportion) with significant improvement in loglikelihood 
Number (proportion) with improvement in AIC 


5 
727 
662 (91.1%) 
674 (92.7%) 
20 
983 
955 (98.3%) 
961 (97.8%) 


Results of whether including adjacent interaction improves modelling of marker haplotype frequencies. Columns refer to 1) the density of marker SNPs (in terms of 1 marker SNP per x SNPs in dataset generated by COSI); 2) the number of sets (out of 1000) where adjacent interactions were not fully predictable from maineffects; 3) the number of sets with adjacent interactions included where they resulted in a significant improvement in model fit (at 5% significance level); 4) the number of sets where including adjacent interactions reduced the AIC. 

Wason and Dudbridge BMC Genetics 2010 11:80 doi:10.1186/147121561180 