Table 2

Interactions between GST genotypes, alcohol consumption, tobacco smoking and fuel source among oesophageal cancer patients and controls

Genotypes

Patients N(%)

Controls N(%)

OR (95%CI) p-value

Patients N(%)

Controls N (%)

OR (95%CI) p-value


Tobacco smokersa

Non smokersa

GSTT1*1

100 (56)

112 (61)

1.00

27 (43)

66 (69)

1.00

GSTT1*0

77 (44)

73 (39)

1.01 (0.62-1.66) 0.951

36 (57)

29 (31)

2.92(1.04-8.16) 0.042

GSTM1*1

151 (85)

125 (68)

1.00

55 (87)

75 (79

1.00

GSTM1*0

125 (15)

60 (32)

0.30 (0.16-0.56) 0.001

8 (13)

20 (21)

0.46 (0.12-1.81) 0.269

GSTP1 313A/A

71 (40)

77 (42)

1.00

21 (33)

30 (32)

1.00

GSTP1 313 A/G

78 (44)

86 (46)

0.96 (0.58-1.61) 0.898

33 (52)

48 (50)

0.53 (0.18-1.51) 0.233

GSTP1 313G/G

28 (16)

22 (12)

1.54 (0.74-3.21) 0.250

9 (14)

17 (18)

0.44 (0.10-1.93) 0.278

GSTP1 341 C/C

106 (60)

166 (90)

1.00

44 (70)

86 (91)

1.00

GSTP1-341C/T + GSTP1-341T/T

71 (40)

19 (10)

7.51 (3.82-14.7) 0.001

19 (30)

9 (9)

5.31 (2.58-27.6) 0.001

Alcohol consumersb

Non consumersb

GSTT1*1

89 (54)

101 (60)

1.00

38 (51)

77 (68)

1.00

GSTT1*0

76 (46)

66 (40)

1.03 (0.60-1.77) 0.911

37 (49)

36 (32)

1.66 (0.77-3.59) 0.197

GSTM1*1

143 (87)

123 (74)

1.00

63 (84)

77 (68)

1.00

GSTM1*0

22 (13)

44 (26)

0.33 (0.16-0.66) 0.002

12 (16)

36 (32)

0.27 (0.10-0.74) 0.011

GSTP1 313A/A

63 (38)

74 (44)

1.00

29 (39)

33 (29)

1.00

GSTP1 313 A/G

80 (48)

75 (45)

1.22 (0.70-2.13) 0.474

31 (41)

58 (52)

0.41 (0.17-0.96) 0.039

GSTP1 313G/G

22 (13)

18 (11)

1.69 (0.72-3.95) 0.226

15 (20)

22 (19)

0.64 (0.24-1.76) 0.394

GSTP1 341 C/C

105 (64)

148 (89)

1.00

45 (60)

104 (92)

1.00

GSTP1-341C/T + GSTP1-341T/T

60 (36)

19 (11)

15.3 (1.81-12.9) 0.012

30 (40)

9 (8)

10.9 (4.09-28.9) 0.001

Wood or charcoal usersc

Non usersc

GSTT1*1

54 (61)

25(58)

1.00

52 (60)

153 (65)

1.00

GSTT1*0

34 (39)

18 (42)

0.77 (0.35-1.68) 0.510

35 (40)

84 (35)

1.67 (0.94-2.93) 0.080

GSTM1*1

72 (82)

27 (63)

1.00

77 (89)

173 (73)

1.00

GSTM1*0

16 (18)

16 (37)

0.41 (0.17-0.96) 0.041

10 (11)

64 (27)

0.26 (0.12-0.56) 0.001

GSTP1 313A/A

38 (43)

17 (40)

1.00

34 (39)

90 (38)

1.00

GSTP1 313 A/G

34 (39)

23 (53)

0.71 (0.30-1.69) 0.441

41 (47)

110 (46)

0.97 (0.55-1.73) 0.922

GSTP1 313G/G

16 (18)

3 (7)

3.28 (0.79-13.7) 0.103

12 (14)

37 (16)

1.11 (0.48-2.53) 0.809

GSTP1 341 C/C

42 (48)

40 (93)

1.00

57 (66)

212 (89)

1.00

GSTP1-341C/T + GSTP1-341T/T

46 (52)

3 (7)

12.1 (3.26-49.0) 0.001

30 (34)

25 (11)

4.93 (2.47-9.84) 0.001


*1 signifies carrier of gene, *0 signifies homozygous gene deletion. Odds ratios adjusted for aalcohol consumption, race, sex, age, wood or charcoal use; btobacco smoking , race, sex, age, wood or charcoal use; calcohol consumption, race, sex, age, tobacco smoking

Li et al. BMC Genetics 2010 11:47   doi:10.1186/1471-2156-11-47

Open Data