Table 1

The distribution of the GST genotypes in Black and Mixed Ancestry in South Africans

Genotypes

Black African subjects

Mixed Ancestry subjects

Analysis of subjects combined

Patients

N (%)

Controls

N (%)

Patients

N (%)

Controls

N (%)

OR1 (95%CI) p-value

OR2 (95%CI) p-value


GSTT1a

*1

57 (40)

109 (59)

68 (68)

69 (73)

1.00

1.00

*0 (rs71748309)

84 (60)

77 (41)

29 (29)

25 (27)

1.55 (1.09-2.21) 0.014

1.71 (1.18-2.46) 0.004

GSTP1 313 A/G (Ile105Val) (rs1695)

313A/A

56 (40)

76 (41)

34 (34)

30 (32)

1.00

313A/G

59 (42)

83 (45)

52 (52)

51 (54)

0.96 (0.66-1.40) 0.846

1.01 (0.68-1.48) 0.973

313G/G

26 (18)

27 (14)

11 (11)

13 (14)

1.08 (0.64-1.82) 0.786

1.21 (0.71-2.07) 0.490

Test for deviation from Hardy-Weinberg Equilibrium

χ2

2.139

0.360

1.874

1.407

p

0.144

0.549

0.177

0.236

313A freq

0.61+0.03

0.63+0.02

0.62+0.03

0.59+0.03

313G freq

0.39+0.03

0.37+0.02

0.38+0.03

0.41+0.03

GSTP1 341 C/T (Ala114Val) (rs1138272)

341C/C

85 (60)

163 (88)

65 (65)

89 (95)

1.00

1.00

341C/T

49 (35)

21 (11)

27 (27)

5 (5)

4.98 (3.05-8.11) 0.001

5.05 (3.06-8.32) 0.001

341T/T

7 (5)

2 (1)

5 (5)

0 (0)

10.9 (2.43-49.1) 0.002

9.58 (2.08-44.0) 0.004

Test for deviation from Hardy-Weinberg Equilibrium

χ2

0

1.397

0.876

0.137

p

0.986

0.237

0.349

0.712

341C freq

0.78+0.02

0.93+0.01

0.81+0.03

0.97+0.01

341T freq

0.22+0.02

0.07+0.01

0.19+0.03

0.03+0.01


OR1, odds ratio not adjusted for confounders; OR2, odds ratio adjusted for the following confounding variables, age, sex, race, tobacco smoking, alcohol consumption and use of wood or charcoal; . a *1 signifies carrier of gene (either homozygous or heterozygous carrier), *0 signifies homozygous gene deletion

Li et al. BMC Genetics 2010 11:47   doi:10.1186/1471-2156-11-47

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