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Open Access Highly Accessed Research article

The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Dongping Li12, Collet Dandara3 and M Iqbal Parker12*

Author Affiliations

1 International Centre for Genetic Engineering and Biotechnology (ICGEB), UCT Campus , Anzio Road Observatory 7925, Cape Town, South Africa

2 Division of Medical Biochemistry, Faculty of Health Science, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa

3 Division of Human Genetics, Faculty of Health Science, University of Cape Town, Anzio Road, Observatory 7925, South Africa

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BMC Genetics 2010, 11:47  doi:10.1186/1471-2156-11-47

Published: 11 June 2010

Additional files

Additional file 1:

Table showing the distribution of the GST genotypes in Black and Mixed Ancestry in South Africans. This Table shows the analysis of the GST genotype distributions in the two populations analysed separately, forming the basis of combined analysis.

Format: DOCX Size: 17KB Download file

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Additional file 2:

Graphs showing an example of relative risk with contributions from different exposure categories (gene-environment interaction). Representative graphs illustrating the interaction between GSTP1 341C/C+T/T genotype with wood/charcoal (graph A) and the interaction between GSTM1*0/*0 genotype with smoking (graph B). In both graphs, U represents is the reference baseline exposure which is GSTP1 341C/C genotype + none exposure to wood/charcoal in graph A; and GSTM1*1/*1 + being non-smoker in graph B. Calculations done according to according to Andersson et al.[39].

Format: DOC Size: 58KB Download file

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