Table 1

P-values from Fisher's exact test calculated for the four viral isolates showing patterns of A to G hypermutations.

Mutated As

Unmutated As

Viral isolate

preferred site*

unpreferred site**

preferred site

unpreferred site

p-value

A3 E55

20

0

89

32

0.007

DM113

20

0

16

11

0.001

U125

4

1

1

5

0.08

Derby

5

0

8

7

0.114

*preferred sites for ADAR-induced hypermutations are As that are preceded by either an A, U or C.

**unpreferred sites for ADAR-induced hypermutations are As that are preceded by a G.

***unmutated sites are defined as As within the cluster of mutations that have not been mutated.

Carpenter et al. BMC Genetics 2009 10:75   doi:10.1186/1471-2156-10-75