Table 2

Domains considered as diagnostic for each protein

Proteins

Diagnostic domains

References


Notch

LNR/EGF/ANK

[23]


Delta

DSL/EGF

[23]


Fringe

Fringe

[80]


Adam 10/17

ZNMc/Disin

[139]


Pres

Peptidase A22

[140]


Nicastrin

M20-dimer superfamily

[141]


APH1

APH1 superfamily

[63]


PEN2

-

[63]


CSL/Su(H)

lag1/IPT RBJ Kappa/beta trefoil

[142]


MAM

Maml - 1

[143]


Numb

numbF/PH-like

[144]


Sno

ABC-ATPase

[26]


Neur

Neur/Zinc finger Ring

[145]


Mib

Mib-herc2/ANK/ZF ring/ZZ Mind

[28]


Deltex

WWE/ZF ring

[25]


NEDD4/Su(dx)

C2/WW/HECT

[146]


Nle

NLE/WD40

[72]


Furin

subtilisin/proprotein convertase/furin

[130]


O-fut

-

[147]


SMRT

SANT

[148]


HES

HLH/Hairy orange

[149]


Gazave et al. BMC Evolutionary Biology 2009 9:249   doi:10.1186/1471-2148-9-249

Open Data