Open Access Highly Accessed Research article

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Eve Gazave1, Pascal Lapébie1, Gemma S Richards2, Frédéric Brunet3, Alexander V Ereskovsky14, Bernard M Degnan2, Carole Borchiellini1, Michel Vervoort56 and Emmanuelle Renard1*

Author Affiliations

1 Aix-Marseille Universités, Centre d'Océanologie de Marseille, Station marine d'Endoume - CNRS UMR 6540-DIMAR, rue de la Batterie des Lions, 13007 Marseille, France

2 School of Biological Sciences, University of Queensland, Brisbane, QLD 4072, Australia

3 Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, INRA, IFR128 BioSciences Lyon-Gerland, Ecole Normale Supérieure de Lyon, 46, Allée d'Italie, 69007 Lyon, France

4 Department of Embryology, Faculty of Biology and Soils, Saint-Petersburg State University, Universitetskaja nab. 7/9, St Petersburg, Russia

5 Institut Jacques Monod, UMR 7592 CNRS/Université Paris Diderot - Paris 7, 15 rue Hélène Brion, 75205 Paris Cedex 13, France

6 UFR de Biologie et Sciences de la Nature, Université Paris 7 - Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France

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BMC Evolutionary Biology 2009, 9:249  doi:10.1186/1471-2148-9-249

Published: 13 October 2009

Additional files

Additional file 1:

Alignments used for the phylogenetic analyses. The data provided represent the alignments used for the 18 phylogenetic analyses.

Format: DOC Size: 415KB Download file

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Open Data

Additional file 2:

Phylogenetic analyses. In this file we provide the phylogenetic trees constructed from the protein alignments using the maximum likelihood method (ML) with the PHYML program for 16 Notch components (excepted Notch and Delta/Jagged).

Format: PDF Size: 212KB Download file

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Open Data

Additional file 3:

Diagnostic domains table. In this table we report the presence or absence of the domains that compose each protein in all species.

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Open Data

Additional file 4:

"Notch-like" in Monosiga brevicollis. The sequence of Monosiga brevicollis presenting a domain arrangement of a Notch gene is provided.

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Open Data

Additional file 5:

Notch phylogenetic tree. Notch phylogenetic tree constructed from the protein alignments using the maximum likelihood method (ML) with the PHYML program.

Format: PDF Size: 167KB Download file

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Open Data

Additional file 6:

DSL phylogenetic tree. DSL proteins phylogenetic tree constructed from the protein alignments using the maximum likelihood method (ML) with the PHYML program.

Format: PDF Size: 242KB Download file

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Open Data

Additional file 7:

Unusual arrangement of DSL domains in Nematostella vectensis. In this file we report the sequences of Nematostella vectensis presenting an unusual arrangement of DSL domains.

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Open Data

Additional file 8:

Strawberry notch sequences. In this file we report the Strawberry notch sequences identified in two heterokonts.

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Open Data