Open Access Highly Accessed Research article

Both selective and neutral processes drive GC content evolution in the human genome

Uberto Pozzoli1, Giorgia Menozzi1, Matteo Fumagalli1, Matteo Cereda1, Giacomo P Comi2, Rachele Cagliani1, Nereo Bresolin12 and Manuela Sironi1*

Author Affiliations

1 Scientific Institute IRCCS E. Medea, Bioinformatic Lab, Via don L. Monza 20, 23842 Bosisio Parini (LC), Italy

2 Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Via F. Sforza 35, 20100 Milan, Italy

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BMC Evolutionary Biology 2008, 8:99  doi:10.1186/1471-2148-8-99

Published: 27 March 2008

Additional files

Additional file 1:

analysis of allele frequency spectra for intergenic regions. The figures provided represent quantile-quantile plots of GC->AT and AT->GC derived allele frequencies for 5' and 3' intergenic sequences.

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Additional file 2:

Analysis of fixed versus polymorphic retrotransposon insertions. The figure provides an analysis of polymorphic and fixed retrotransposon relative frequency in different isochores (identified as described in [50])

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Additional file 3:

substitution rates and GC* in intergenic regions. The data provided represent tables of substitution rates and GC* for 3' and 5' intergenic regions.

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Additional file 4:

Analysis of GC content distribution and size for human introns. the data provide an analysis of intron size and GC content calculated after repeat removal. Also, additional data concerning the relationship between intron size and GC content are shown: in particular, both a different isochore identification procedure was applied and the gene GC content instead of isochore location were used.

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