Research article
Selection against tandem splice sites affecting structured protein regions
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* Corresponding author: Michael Hiller hiller@informatik.uni-freiburg.de
1 Bioinformatics Group, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee 106, 79110 Freiburg, Germany
2 Genome Analysis, Leibniz Institute for Age Research – Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany
BMC Evolutionary Biology 2008, 8:89 doi:10.1186/1471-2148-8-89
Published: 21 March 2008Additional files
Additional file 1:
Supplementary Text.
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Additional file 2:
Overlap between the protein features.
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Additional file 3:
Frequency of tandem splice sites in different protein features.
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Additional file 4:
Selection against insertion of particular amino acids.
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Additional file 5:
Distribution of the insertion sequences of tandem sites in the protein features.
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Additional file 6:
Association of tandem sites with specific Pfam domains or clans.
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Additional file 7:
Avoidance of NAGNAG sites in structured regions of Pfam domains.
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Additional file 8:
Distribution of plausible and implausible NAGNAG acceptors in different protein features.
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Additional file 9:
Supplementary Methods
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Additional file 10:
Unequal distribution of the target mutations between plausible and implausible human pre-NAGNAG sites and between CDS/UTR and order/disorder.
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Additional file 11:
Average hydropathy scores for introns without tandem donor or acceptor motifs (control introns) and for introns with tandem donors and acceptors.
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