Table 3

Gene Families With Potential HGT
			Number of HGT events
Gene Family	Poxvirus Genera	Family Size ¶	Phylogeny	Gene Order	Reference

Candidate HTgenes identified by PSI-BLAST search

dUTPase	entomo, avi, para, ortho, clade II	137	2 †	*	[51,52]
Glutathione peroxidase	avi, mollusci	42	2 §	2	[11]
GNS1	avi	18	1	1
Interleukin-10	avi, para, yata, capri	145	2 †§	≥ 2	[11,25]
Ribonucleotide reductase, large subunit	ortho, sui	90	1	1	[11]
Ribonucleotide reductase, small subunit	croc, avi, or-tho, clade II	178	3 †	2	[11,37]
S1R/CGI-119	ortho	36	1	1 ‡
Serpin	avi, ortho, clade II	272	1 §	-	[11,53]
Thymidine kinase	entomo, avi, ortho, clade II	143	? †§	2–3	[29,34]

Candidate HTgenes from the literature

NlpC/P60 peptidase (G6R)	all			1	[21]
CD47	ortho, clade II			1	[11]
Deoxycytidine kinase	avi			1	[11]
Glutaredoxin	ortho			1	[11]
Hydroxysteroid dehydro-genase	avi, mollusci, ortho, yata, deer, sui			1	[11]
MHC 1	yata, sui, deer			1	[11]
Deoxyribodipyrimidine photolyase	entomo, avi, lepori			≥ 2	[11]
α(2,3)-sialtransferase	lepori, deer			1	[11]
α-soluble NSF attachment protein (SNAP)	avi			1	[11]
Profilin	ortho			1	[11]
DNA-directed RNA poly-merase, subunit A	all			1	[11]
Carbonic anhydrase	ortho, lepori			1	[11]
Superoxide dismutase	entomo, ortho, lepori, sui, deer, capri			1	[11]
Uracil DNA glycolase	entomo			*	[11]
Interferon gamma receptor	ortho, lepori, sui, deer, capri			*	[11]

¶ Poxvirus family members and all homologs identified in PSI-BLAST search † No bootstrap support (≥ 80%) for critical branches ‡ Followed by gene duplication § Previously described as polyphyletic in poxviruses * Insufficient synteny conservation
Bratke and McLysaght BMC Evolutionary Biology 2008 8:67 doi:10.1186/1471-2148-8-67