Table 3

Gene Families With Potential HGT

Number of HGT events

Gene Family

Poxvirus Genera

Family Size ¶

Phylogeny

Gene Order

Reference

Candidate HTgenes identified by PSI-BLAST search

dUTPase

entomo, avi, para, ortho, clade II

137

2 †

*

[51,52]

Glutathione peroxidase

avi, mollusci

42

2 §

2

[11]

GNS1

avi

18

1

1

Interleukin-10

avi, para, yata, capri

145

2 †§

≥ 2

[11,25]

Ribonucleotide reductase, large subunit

ortho, sui

90

1

1

[11]

Ribonucleotide reductase, small subunit

croc, avi, or-tho, clade II

178

3 †

2

[11,37]

S1R/CGI-119

ortho

36

1

1 ‡

Serpin

avi, ortho, clade II

272

1 §

-

[11,53]

Thymidine kinase

entomo, avi, ortho, clade II

143

? †§

2–3

[29,34]

Candidate HTgenes from the literature

NlpC/P60 peptidase (G6R)

all

1

[21]

CD47

ortho, clade II

1

[11]

Deoxycytidine kinase

avi

1

[11]

Glutaredoxin

ortho

1

[11]

Hydroxysteroid dehydro-genase

avi, mollusci, ortho, yata, deer, sui

1

[11]

MHC 1

yata, sui, deer

1

[11]

Deoxyribodipyrimidine photolyase

entomo, avi, lepori

≥ 2

[11]

α(2,3)-sialtransferase

lepori, deer

1

[11]

α-soluble NSF attachment protein (SNAP)

avi

1

[11]

Profilin

ortho

1

[11]

DNA-directed RNA poly-merase, subunit A

all

1

[11]

Carbonic anhydrase

ortho, lepori

1

[11]

Superoxide dismutase

entomo, ortho, lepori, sui, deer, capri

1

[11]

Uracil DNA glycolase

entomo

*

[11]

Interferon gamma receptor

ortho, lepori, sui, deer, capri

*

[11]

¶ Poxvirus family members and all homologs identified in PSI-BLAST search

† No bootstrap support (≥ 80%) for critical branches

‡ Followed by gene duplication

§ Previously described as polyphyletic in poxviruses

* Insufficient synteny conservation

Bratke and McLysaght BMC Evolutionary Biology 2008 8:67   doi:10.1186/1471-2148-8-67