Table 2

Transmembrane domain inter-loop length (amino-acids)

NH₂ (I)

L1 (O)

L2 (I)

L3 (O)

L4 (I)

L5 (O)

L6 (I)

L7 (O)

L8 (I)

L9 (O)

L10 (I)

L11 (O)

COOH (I)

Mouse Otop1

58^#

12^#

23

10

11

50

21

9

19

11

85

16

13^#

Rat Otop1

58

12

23

10

11

50

21

9

19

11

85

16

13

Human OTOP1

61

12

23

10

11

50

21

9

19

11

95

16

13

Chimp Otop1

61

12

23

10

11

50

21

9

19

11

95

16

13

Rhesus Otop1

61

12

23

10

11

50

21

9

19

11

93

16

13

Chicken Otop1

11*

12

23

10

11

50

21

9

19

11

98

16

13

X. tropicalis Otop1

39

12

23

10

11

47

21

9

19

11

96

16

13

Zebrafish Otop1

54

12

23

10

11

47

22

9

19

11

75

16

13

Medaka Otop1

52

12

23

10

11

49

22

9

19

11

73

16

13

Stickleback Otop1

51

12

24

10

11

47

22

9

19

11

87

16

13

Fugu Otop1

51

12

23

10

11

47

22

9

19

11

87

16

13

Tetraodon Otop1

50

12

23

10

11

47

22

9

19

11

87

16

12

Mouse Otop2

30

12

23

10

11

54

26

9

19

11

67

16

13

Rat Otop2

30

12

23

10

11

54

26

9

19

11

67

16

13

Human OTOP2

30

12

23

10

11

53

26

9

19

11

67

16

13

Chimp Otop2

30

12

23

10

11

53

26

9

19

11

67

16

13

Dog Otop2

30

12

23

10

11

53

26

9

19

11

67

16

13

Cow Otop2

30

12

23

10

11

53

26

9

19

11

67

16

13

Armadillo Otop2

30

12

23

10

11

53

26

9

19

11

67

16

13

Opossum Otop2

30

12

23

10

11

46

32

6

19

11

65

16

13

X. tropicalis Otop2

31*

12

22

10

11

54

25

8

19

11

62

16

13

Stickleback Otop2

31*

12

23

10

11

52

20

12

19

11

64

16

13

Mouse Otop3

70

12

23

10

11

44

24

8

19

11

54

16

13

Rat Otop3

71

12

23

10

11

44

24

8

19

11

54

16

13

Human OTOP3

89

12

23

10

11

44

24

8

19

11

54

16

13

Dog Otop3

71

12

23

10

11

44

24

8

19

11

54

16

13

Opossum Otop3

59*

12

23

10

11

44

24

8

19

11

58

16

13

Platypus Otop3

51*

12

23

10

11

44

24

8

19

11

51

16

13

Chicken Otop3

24

12

23

10

11

44

23

8

19

11

62

16

13

X. tropicalis Otop3

34

12

23

10

11

43

22

8

19

11

46

16

13

Stickleback Otop3

48

12

23

10

11

45

28

8

19

11

60

16

13

Fugu Otop3

1*

12

23

10

11

45

27

8

19

11

44

16

11

D. melanogaster OTOPLa

64

14

79

13

11

337

43

8

15

9

14

16

19

A. gambiae OTOPLa

65

14

69

13

11

264

43

8

15

9

14

16

19

A. mellifera. OTOPLa

73

14

74

13

11

202

44

8

15

9

14

16

19

T. castaneum OTOPLa

65

14

79

13

11

148

42

8

15

9

14

16

19

D. melanogaster OTOPLb

76

14

26

13

12

94

34

8

20

10

14

16

19

D. pseudoobscura OTOPLb

76

14

26

13

12

94

34

8

20

10

14

16

19

A. gambiae OTOPLb1

26

14

28

13

12

91

37

8

21

10

14

16

22

A. aegypti OTOPLb1

197

14

26

13

12

87

37

8

21

10

14

16

22

T. castaneum OTOPLb

106

14

34

14

12

43

35

13

21

7

14

16

31

A. gambiae OTOPLb2

163

14

32

13

12

60

41

8

19

7

14

16

21

A. aegypti OTOPLb2

157

14

29

13

13

75

35

8

18

10

14

16

21

D. melanogaster OTOPLc

0*

14

60

13

12

73

34

8

15

7

14

16

115

D. pseudoobscura OTOPLc

0*

14

59

13

12

74

34

8

15

7

14

16

90

A. gambiae OTOPLc

7*

14

70

13

12

70

33

8

15

7

14

16

21

A. aegypti OTOPLc

10

14

68

13

12

70

33

8

15

7

14

16

21

A. mellifera OTOPLc

90

14

46

13

12

74

37

8

15

7

14

16

21

T. castaneum OTOPLc

177

14

50

13

12

79

33

8

15

7

14

16

21

C. elegans OTOPLd1

38

14

31

9

11

59

25

7

16

10

14

13

36

C. briggsae OTOPLd

47

14

34

9

11

59

25

7

16

10

14

13

37

C. elegans OTOPLd2

55

14

34

9

11

59

25

7

16

10

12

13

38

C. elegans OTOPLe

50

14

36

9

11

69

22

7

16

11

14

13

34

C. briggsae OTOPLe

42

14

36

9

11

67

22

7

16

11

14

13

37

C. elegans OTOPLf

65

14

35

9

11

93

25

7

16

10

14

13

38

C. briggsae OTOPLf

71

14

36

9

11

99

25

7

16

10

14

13

48

C. elegans OTOPLg

64

13

34

9

11

72

26

7

16

11

14

13

53

C. briggsae OTOPLg

64

13

34

9

11

73

26

7

16

11

14

13

55

C. elegans OTOPLh

56

17

81

9

11

75

25

7

22

11

13

16

34

C. briggsae OTOPLh

66

17

47

9

11

70

25

7

22

11

13

16

34

C. elegans OTOPLi

51

18

29

14

11

46

27

5

22

10

16

16

30

C. briggsae OTOPLi

51

18

30

14

11

48

27

5

22

10

16

16

30

Average

62.4

13.2

33.7

10.8

11.2

70.5

27.6

8.1

18.2

10.2

43.1

15.6

23.2

SD

37.3

1.5

17.0

1.6

0.5

50.2

6.5

1.2

2.0

1.4

30.6

1.1

18.3

^#Number of amino-acid residues within the N-terminal, interloop, and C-terminal domains. (I), inner loop; (O), outer loop; SD, standard deviation.*Incomplete N-terminal sequence data were excluded from N-terminal loop length calculations.

Hughes et al. BMC Evolutionary Biology 2008 8:41   doi:10.1186/1471-2148-8-41