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Open AccessResearch article

Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy

Nina Peitsaro1,2 email, Zydrune Polianskyte1,2 email, Jarno Tuimala3 email, Isabella Pörn-Ares1,2 email, Julius Liobikas2 email, Oliver Speer2 email, Dan Lindholm4 email, James Thompson5 email and Ove Eriksson1,2 email

Research Program of Molecular Neurology, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland

Helsinki Biophysics and Biomembrane Group, Institute of Biomedicine, P.O. Box 63, FIN-00014 University of Helsinki, Finland

CSC-Scientific Computing Ltd, P.O. Box 405, FIN-02101 Espoo, Finland

Minerva Medical Research Institute, Biomedicum Helsinki, FIN-00290 Helsinki, Finland

Androgen Receptor Laboratory, Institute of Biomedicine, P.O. Box 63, FIN-00014 University of Helsinki, Finland

author email corresponding author email

BMC Evolutionary Biology 2008, 8:26doi:10.1186/1471-2148-8-26

Published: 28 January 2008

Additional files

Additional file 1:

Accession Numbers and Classification of a Set of Founding Members of the PBP-βL classes. Contains a list of founding members of the different PBP-βL classes including additional references.

Format: DOC Size: 117KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 2:

Conserved Structural Elements in LPBP-Bs and LACTB. Contains a list of amino acids in conserved motifs found in LPBP-B proteins and LACTB.

Format: DOC Size: 76KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 3:

Conserved PBP-βL signature motifs in LACTB family proteins. Multiple amino acid alignment of PBP-βL signature motif-containing segments from LACTB family proteins.

Format: TIFF Size: 7.9MB Download file


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