Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

doi:10.1186/1471-2148-8-225

BMC Evolutionary Biology

Volume 8

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Fontanella B
Ballabio A
Meroni G

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Research article

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

Marco Sardiello¹ , Stefano Cairo¹^,3 , Bianca Fontanella¹^,4 , Andrea Ballabio¹^,2 and Germana Meroni¹

¹Telethon Institute of Genetics and Medicine (TIGEM), Via P. Castellino 111, 80131 Naples, Italy

²Department of Pediatrics, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy

³Unite d'Oncogenèse et Virologie Moléculaire, Batiment Lwoff, Institut Pasteur, 28 rue de Dr. Roux, 75724 Paris Cedex 15, France

⁴Department of Pharmaceutical Sciences, University of Salerno, 84084 Fisciano (SA), Italy

author email corresponding author email

BMC Evolutionary Biology 2008, 8:225doi:10.1186/1471-2148-8-225


Published:	1 August 2008

Additional files

Additional file 1:

Includes the alignments of the RING, B-box1 and B-box2 domains of all the human TRIM and TRIM-like proteins, alignments from which the consensi for these domains have been generated.

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Additional file 2:

Reports the values of Coiled-coil predictions for all the human TRIM and TRIM-like proteins.

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Additional file 3:

Shows the unrooted phylogenetic trees generated from the alignments of single domains of the tripartite motif.

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Additional file 4:

Shows a schematic representation of the human TRIM genomic clusters.

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Additional file 5:

Shows comparative and evolutionary analyses of the cluster of TRIM5, 6, 22, and 34 in mammals.

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