Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations

doi:10.1186/1471-2148-8-188

BMC Evolutionary Biology

Volume 8

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Research article

Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations

Heather A Jackson and Eric A Accili

Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada

author email corresponding author email

BMC Evolutionary Biology 2008, 8:188doi:10.1186/1471-2148-8-188


Published:	30 June 2008

Additional files

Additional file 1:

A list of AAMs and nsSNPs in KCNQ1 and HERG used in the analyses. A list of all disease mutations and SNPs which were used in these analyses along with their location within each channel, the disease phenotype with which they are associated and the database reference from which they were collected.

Format: XLS Size: 70KB Download file

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