Location of positively selected sites in the MPO structure and their effect on bonding within the structure. (a) 3-D structure of the human MPO sequence, highlighted in gold are those sites that are positively selected in MPO, in blue is the heme binding site. (b) Example of the affect on hydrogen bonding of one such mutation at positively selected position 496 in human MPO from Asparagine to Phenylalanine.
Loughran et al. BMC Evolutionary Biology 2008 8:101 doi:10.1186/1471-2148-8-101