Email updates

Keep up to date with the latest news and content from BMC Evolutionary Biology and BioMed Central.

This article is part of the supplement: First International Conference on Phylogenomics

Open Access Research

Assembly rules for protein networks derived from phylogenetic-statistical analysis of whole genomes

Mark Pagel*, Andrew Meade and Daniel Scott

Author Affiliations

School of Biological Sciences, University of Reading, Reading RG6 6AJ, UK

For all author emails, please log on.

BMC Evolutionary Biology 2007, 7(Suppl 1):S16  doi:10.1186/1471-2148-7-S1-S16

Published: 8 February 2007

Abstract

Background

We report an analysis of a protein network of functionally linked proteins, identified from a phylogenetic statistical analysis of complete eukaryotic genomes. Phylogenetic methods identify pairs of proteins that co-evolve on a phylogenetic tree, and have been shown to have a high probability of correctly identifying known functional links.

Results

The eukaryotic correlated evolution network we derive displays the familiar power law scaling of connectivity. We introduce the use of explicit phylogenetic methods to reconstruct the ancestral presence or absence of proteins at the interior nodes of a phylogeny of eukaryote species. We find that the connectivity distribution of proteins at the point they arise on the tree and join the network follows a power law, as does the connectivity distribution of proteins at the time they are lost from the network. Proteins resident in the network acquire connections over time, but we find no evidence that 'preferential attachment' – the phenomenon of newly acquired connections in the network being more likely to be made to proteins with large numbers of connections – influences the network structure. We derive a 'variable rate of attachment' model in which proteins vary in their propensity to form network interactions independently of how many connections they have or of the total number of connections in the network, and show how this model can produce apparent power-law scaling without preferential attachment.

Conclusion

A few simple rules can explain the topological structure and evolutionary changes to protein-interaction networks: most change is concentrated in satellite proteins of low connectivity and small phenotypic effect, and proteins differ in their propensity to form attachments. Given these rules of assembly, power law scaled networks naturally emerge from simple principles of selection, yielding protein interaction networks that retain a high-degree of robustness on short time scales and evolvability on longer evolutionary time scales.