Proximity of the human family GH18 genes to the human MHC paralogon on chromosome 1. An ideogram from NCBI Map Viewer shows human chromosome 1 with region encoding MHC paralogon genes boxed in red. Arrows point to the locations of the human family GH18 genes (symbols underlined to distinguish them from MHC related genes) and representative genes from the MHC paralogous region. The choice of genes is based on a recent comparative analysis of the MHC . The MHC paralog symbols are: LYPLA2, lysophospholipase II (1p36.12-p35.1); DDAH1, dimethylarginine dimethylaminohydrolase 1 (1p22); BRDT, bromodomain, testis-specific (1p22.1); COL11A1, collagen, type XI alpha 1 (1p21); VAV3, vav 3 oncogene (1p13.3), DDR2, discoidin domain receptor family, member 2 (1q12-q23); RXRG, retinoid X receptor, gamma, 1q22-q23); TNFS4, tumor necrosis factor (ligand) superfamily, member 4 (1q25); PTGS2, prostaglandin-endoperoxide synthase 2 (1q25.2-q25.3); and B3GALT2, UDP-Gal:beta GlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (1q31).
Funkhouser and Aronson BMC Evolutionary Biology 2007 7:96 doi:10.1186/1471-2148-7-96