Figure 1.

Increased mutation rates in closed chromatin at non-CpG sites. (A+B) Mean intergenic and ancient repeat divergence observed across chromatin categories (Intergenic r²: = 0.87, p = 9.1e-05; Intergenic repeats only r²: = 0.93, p = 7.3e-06; Ancient repeats only r²: = 0.93, p = 6.1e-06). (C) Intergenic divergence of each 1 Mb clone from chromosome 1 against their corresponding chromatin score (10 clones containing less than 10,000 intergenic bases were excluded). (D) Mean human SNP densities (SNPs/bp) observed across chromatin categories (All SNPs r²: = 0.89, p = 0.016; Single random detection protocol (TSCM0019) SNPs only r²: = 0.93, p = 0.008).