Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

doi:10.1186/1471-2148-7-24

BMC Evolutionary Biology

Volume 7

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Ollikainen N

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Research article

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

Michael E Baker , Charlie Chandsawangbhuwana and Noah Ollikainen

Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA

author email corresponding author email

BMC Evolutionary Biology 2007, 7:24doi:10.1186/1471-2148-7-24


Published:	16 February 2007

Additional files

Additional File 1:

3D structure of the conserved glutamic acid in the AF2 domain. The conserved glutamic acid in the AF2 domain in α-helix 12 on the GR has a different orientation than the corresponding glutamic acid in the MR, PR and AR. Oε2 on the GR Glu-755 is 3.4 A from Oε2 on MR Glu-962.

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