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Open AccessHighly AccessResearch article

Functional evolution of the vitamin D and pregnane X receptors

Erica J Reschly1 email, Afonso Celso Dias Bainy2 email, Jaco Joaquim Mattos2 email, Lee R Hagey3 email, Nathan Bahary4 email, Sripal R Mada5 email, Junhai Ou5 email, Raman Venkataramanan5 email and Matthew D Krasowski1 email

1Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA

2Departamento de Bioquimica, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

3Department of Medicine, University of California at San Diego, San Diego, CA, USA

4Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA

5Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA

author email corresponding author email

BMC Evolutionary Biology 2007, 7:222doi:10.1186/1471-2148-7-222

Published: 12 November 2007

Additional files

Additional File 1:

Sequence alignment of PXRs and VDRs.

Format: PDF Size: 24KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional File 2:

Conservation of VDR and PXR ligand-binding residues across species.

Format: PDF Size: 94KB Download file

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Additional File 3:

Additional data for Xenopus laevis, zebrafish, and sea lamprey VDRs.

Format: XLS Size: 47KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional File 4:

Effect of compounds on testosterone hydroxylation in primary cultures of African clawed frog hepatocytes.

Format: PDF Size: 697KB Download file

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