Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

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Manuel Irimia^*, Jakob L Rukov, David Penny and Scott W Roy^*

* Corresponding authors: Manuel Irimia mirimia@gmail.com - Scott W Roy scottwroy@gmail.com

BMC Evolutionary Biology 2007, 7:188 doi:10.1186/1471-2148-7-188

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Eukaryotes compensate for inefficient splicing by mechanisms that prevent the translation of mis-spliced or unspliced mRNAs.