Table 3 |
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M. avium paratuberculosis PE and PPE genes* |
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PE genes |
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TIGR gene number |
Primary gene number |
M. tuberculosis orthologue gene number |
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NT03MA0124 |
MAP0122 |
Rv1386 |
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NT03MA1039 |
MAP1003c |
Rv1040c (included in the same sequence as Rv1039c – see below) |
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NT03MA0159 |
MAP0157 |
Rv3893c |
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NT03MA0465 |
MAP0441 |
Rv3622c |
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Not annotated (NT03MA1570.1) |
- |
Rv1788 |
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NT03MA1572 |
MAP1507 |
Rv1791 |
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NT03MA1580 |
MAP1514 |
Region 5 |
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NT03MA2703 |
MAP2576c |
Probably Rv1195, but have been rearranged |
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NT03MA3983 |
MAP3781 |
Rv0285 |
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NT03MA4378 |
MAP4144 |
Absent in M. tuberculosis – situated between Rv0685 and Rv0686 – most homologous to PE Rv3595c |
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PPE genes |
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TIGR gene number |
Primary gene number |
M. tuberculosis orthologue gene number |
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NT03MA0125 |
MAP0123 |
Rv1387 |
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NT03MA0160 |
MAP0158 |
Rv3892c |
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NT03MA0467 |
MAP0442 |
Rv3621c |
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NT03MA0998 |
MAP0966c |
Absent in M. tuberculosis – Situated between Rv1006 and Rv1007 next to a transposase – most homologous to the PPE Rv1789 |
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NT03MA1039 |
MAP1003c |
Rv1039c (also includes Rv1040c in the same sequence) |
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NT03MA1194 |
MAP1144c |
Absent in M. tuberculosis – Situated between Rv1417 and Rv1420-most homologous to the PPE Rv0280 |
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NT03MA1201 |
MAP1152 |
Absent in M. tuberculosis – Situated between Rv1423 and Rv1425 next to a transposase – most homologous to the PPE Rv1808 and Rv1801 |
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NT03MA1202 |
MAP1153 |
Absent in M. tuberculosis – Situated between Rv1423 and Rv1425-most homologous to the PPE Rv1809 |
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NT03MA1204 |
MAP1155 |
Absent in M. tuberculosis – Situated between Rv1423 and Rv1425-most homologous to the PPE Rv1807 |
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NT03MA1570 |
MAP1505 |
Rv1787 |
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NT03MA1571 |
MAP1506 |
Rv1789 |
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NT03MA1581 |
MAP1515 |
Region 5 – most homologous to Rv1807 |
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NT03MA1582 |
MAP1516 |
Region 5 – most homologous to Rv1807 |
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NT03MA1585 |
MAP1518 |
Region 5 – most homologous to Rv1808 |
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NT03MA1586 |
MAP1519 |
Region 5 – most homologous to Rv1809 and Rv1802 |
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NT03MA1589 |
MAP1521 |
Region 5 – most homologous to Rv1808 and Rv1801 |
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NT03MA1590 |
MAP1522 |
Region 5 – most homologous to Rv1809 |
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NT03MA1746 |
MAP1675 |
Absent in M. tuberculosis – Situated between large number of M. avium genes absent from M. tuberculosis – most homologous to PPE Rv3621c |
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NT03MA1809 |
MAP1734 |
Absent in M. tuberculosis – Situated between large number of M. avium genes absent from M. tuberculosis – most homologous to PPE Rv2123 |
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NT03MA1810 |
- |
Absent in M. tuberculosis – Situated between large number of M. avium genes absent from M. tuberculosis – most homologous to PPE Rv0280 |
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NT03MA1895 |
MAP1813c |
Absent in M. tuberculosis – Situated between Rv2066 and Rv2069 – most homologous to PPE Rv0256c |
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NT03MA2236 |
MAP2136c |
Situated between Rv2348 and Rv2357c, in other words in the position of PPE Rv2352, Rv2353 or Rv2356, but does not contain MPTR tail and shows most homology to PPE Rv1789 |
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NT03MA2702 |
MAP2575c |
Probably Rv1196, but have been rearranged |
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NT03MA2725 |
MAP2595 |
Absent in M. tuberculosis – Situated between Rv1186c and Rv1185c – most homologous to PPE Rv0256c |
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NT03MA2730 |
MAP2600 |
Absent in M. tuberculosis – Situated between Rv1185c and Rv1181 – most homologous to PPE Rv1807 |
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NT03MA2731 |
MAP2601 |
Absent in M. tuberculosis – Situated between Rv1185c and Rv1181 – most homologous to PPE Rv1808 |
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NT03MA3070 |
MAP2927 |
Absent in M. tuberculosis – Situated between Rv2856 and Rv2857c – most homologous to PPE Rv2892c |
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NT03MA3359 |
MAP3184 |
Rv3135 |
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NT03MA3360 |
MAP3185 |
Rv3136 |
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NT03MA3611 |
MAP3419c |
Absent in M. tuberculosis – Situated between Rv3298c and Rv3300c – most homologous to PPE Rv1789 |
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NT03MA3612 |
MAP3420c |
Absent in M. tuberculosis – Situated between Rv3298c and Rv3300c – most homologous to PPE Rv1809 |
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NT03MA3690 |
MAP3490 |
Absent in M. tuberculosis – Situated between Rv3396c and Rv3400 – most homologous to PPE Rv0280 |
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NT03MA3934 |
MAP3725 |
Rv0280 |
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NT03MA3944 |
MAP3737 |
Absent in M. tuberculosis – Situated between large number of M. avium genes absent from M. tuberculosis – most homologous to PPE Rv0256c |
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NT03MA3967 |
MAP3765 |
Absent in M. tuberculosis – Situated between large number of M. avium genes absent from M. tuberculosis – most homologous to PPE Rv0280 |
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NT03MA3984 |
MAP3782 |
Rv0286 |
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NT03MA4150 |
MAP3939c |
Rv0442c – Situated between Rv0441c and Rv0443, in other words in the position of PPE Rv0442c, but does not contain MPTR tail although it shows most homology to PPE Rv0442c |
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*The genes NT03MA3679 and NT03MA4076 was annotated as PE_PGRS family proteins in the TIGR annotation, but they are in fact not. NT03MA3679 is an orthologue of Rv3390 (lpqD), while NT03MA4076 is a gene which is absent in M. tuberculosis (situated between Rv0358 and Rv0357c). Although it is slightly homologous to the PE_PGRS Rv0754, this homology is only to bp 280 – 520 of the 584 bp PE_PGRS sequence (this region of homology is also highly homologous to lpqD and consists of a biphosphatase and phosphoglycerate mutase signature). It also does not contain the conserved PE N-terminus and is thus highly unlikely to be a PE_PGRS member. |
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Gey van Pittius et al. BMC Evolutionary Biology 2006 6:95 doi:10.1186/1471-2148-6-95 |
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