Table 2 |
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|
Paired genes present in both the PE and PPE multigene families.* |
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|
Sub-Lineage** |
Paired genes |
Associated ESAT-6 (esx) gene cluster region*** |
|
|
|
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|
(PE) |
(PPE) |
||
|
|
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|
I |
Rv3872 |
Rv3873 |
Situated in ESAT-6 (esx) gene cluster region 1 |
|
II |
Rv0285 |
Rv0286 |
Situated in ESAT-6 (esx) gene cluster region 3 |
|
II |
Rv3018A |
Rv3018c |
Duplicated from ESAT-6 (esx) gene cluster region 3 |
|
II |
Rv3022A |
Rv3021/22c |
Duplicated from ESAT-6 (esx) gene cluster region 3 |
|
II |
Rv1386 |
Rv1387 |
Associated with ESAT-6 (esx) gene cluster region 3 |
|
III |
Rv3893c |
Rv3892c |
Situated in ESAT-6 (esx) gene cluster region 2 |
|
III |
Rv2107 |
Rv2108 |
Associated with ESAT-6 (esx) gene cluster region 2 |
|
III or IV |
Rv2431c |
Rv2430c |
Associated with ESAT-6 (esx) gene cluster region 2 or 5 |
|
IV |
Rv1788/91 |
Rv1787/89/90 |
Situated in ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv3622c |
Rv3621c |
Duplicated from ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv1195 |
Rv1196 |
Duplicated from ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv1040c |
Rv1039c |
Duplicated from ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv1169c |
Rv1168c |
Associated with ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv1806 |
Rv1801/2/7/8/9 |
Associated with ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv3477 |
Rv3478 |
Associated with ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv2769c |
Rv2768c/70c |
Associated with ESAT-6 (esx) gene cluster region 5 |
|
IV |
Rv0916c |
Rv0915c |
Associated with ESAT-6 (esx) gene cluster region 5 |
|
|
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|
* Although they are physically-separated, Rv3746c and Rv3739c seems to have been a pair associated with either ESAT-6 gene cluster region 1 or 3, which was disrupted by the insertion of a number of genes. ** See Figure 5 and 6 for definition of sublineages. *** "Situated in" denotes genes situated within ESAT-6 (esx) gene cluster regions, "Duplicated from" denotes genes confirmed to be duplicated from ESAT-6 (esx) gene clusters due to the presence of ESAT-6 and CFP-10 genes immediately adjacent to them, "Associated with" denotes genes which are hypothesized to have been duplicated from ESAT-6 (esx) gene cluster regions, as they are very homologous to their paralogues within the clusters (see Figure 1). |
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Gey van Pittius et al. BMC Evolutionary Biology 2006 6:95 doi:10.1186/1471-2148-6-95 |
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