Recurring genomic breaks in independent lineages support genomic fragility
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* Corresponding author: Sridhar Hannenhalli sridharh@pcbi.upenn.edu
BMC Evolutionary Biology 2006, 6:90 doi:10.1186/1471-2148-6-90
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BioMed Central: 4 citations
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Proceedings
The rise and fall of breakpoint reuse depending on genome resolution Oliver Attie, Aaron E Darling, Sophia Yancopoulos BMC Bioinformatics 2011, 12(Suppl 9):S1 (5 October 2011) |
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Research
Comparative genomics reveals birth and death of fragile regions in mammalian evolution Max A Alekseyev, Pavel A Pevzner Genome Biology 2010, 11:R117 (30 November 2010) A new model explains the frequencies of breakpoints at genomic rearrangement hotspots by demonstrating that fragile sites undergo birth and death.
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Research article
Claire Lemaitre, Lamia Zaghloul, Marie-France Sagot, Christian Gautier, Alain Arneodo, Eric Tannier, Benjamin Audit BMC Genomics 2009, 10:335 (24 July 2009) Mammalian evolutionary breakpoints occur frequently in GC-rich intergenic regions characteristic of high-transcriptional activity and replication initiation, suggesting that their distribution is linked to natural selection and a mutational bias due to local open chromatin state.
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Research article
Precise detection of rearrangement breakpoints in mammalian chromosomes Claire Lemaitre, Eric Tannier, Christian Gautier, Marie-France Sagot BMC Bioinformatics 2008, 9:286 (18 June 2008) By comparing an organism's chromosomes to those of closely related species using a segmentation algorithm, breakpoints can be precisely delimited and their internal structure described, providing insights into the mechanisms and evolutionary properties of chromosomal rearrangements.
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