Additional file 1.

Prediction of transmembrane domains (TMs) in human GnRHR1 and Ce-GnRHR. The sequence alignment of human GnRHR1 and Ce-GnRHR presented here is taken from Figure 1; Thus for consistency, some sites are represented by gaps in both sequences. Functionally important residues (FIRs) are colored (see legend for classification). Overall, there is 56 % similarity between the FIRs of human GnRHR1 and Ce-GnRHR. TMs for both human GnRHR1 and the Ce-GnRHR were predicted using multiple programs described in Methods and are represented as colored lines above/below the alignment. Each program predicted Ce-GnRHR, like human GnRHR1, to have 7 TMs.

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Vadakkadath Meethal et al. BMC Evolutionary Biology 2006 6:103   doi:10.1186/1471-2148-6-103