Table 2

Examples of horizontally transferred genes in TT and DR

Selected horizontally transferred genes/operons

T. thermophilus Protein ID

D. radiodurans Protein ID

Comment


Xenologous gene displacement

Ribosomal protein L15 (COG0200)

TTC1309

DR2115

Proteobacterial affinity of DR; Affinity to Thermatoga/Aquifex/other Gram-positive bacteria in TT

Ribosomal protein L30/L7E (COG1841)

TTC1310

DR2114

Thermatogales/Aquifecales version in TT, affinity to other bacteria in DR

Thiamine biosynthesis protein ThiC (COG0422)

TTC0319

DRA0175

Proteobacterial affinity in DR; Cyanobacteria/Actinobacterial affinity in TT

Threonine synthase (COG0498)

TTC0117

DRA0360

Proteobacterial version in DR; Cyanobacteria/Actinobacterial affinity in TT

Trk system potassium uptake protein trkG, trkA (COG0168, COG0569)

TT0809, TT0810

DR1667, DR1668; DR1666

Archaeal version in TT; Gram-positive version in DR

Ribonucleoside-diphosphate reductase alpha chain and beta chains (COG0208, COG0209)

TTP0162, TTP0161

DRB0108, DRB0109

Proteobacterial affinity for TT; affinity with Gram-positive bacteria in DR

Paralogous genes acquisition

5-formyltetrahydrofolate cyclo-ligase (COG0212)

TTC1247, TTC1803

DR1815

Gram-positive version in DR and TT; additional pseudoparalog TT1803 appears to be of archaeal origin

Non-orthologous gene displacement/acquisition

Thymidylate synthase

TTC0731 (COG1351)

DR2630 (COG0207)

Represented by two non-homologous genes in DR (protobacterial version) and TT (orthologs in Treponema, Wolbachia)

Purine-nucleoside phosphorylase (purine degradation enzyme)

TTC1070 (COG0813) TTC0194 (COG0005)

DR2166 (COG0813)

TT has two non-homologous enzymes; TTC0194 probably was acquired from a thermopilic source


Omelchenko et al. BMC Evolutionary Biology 2005 5:57   doi:10.1186/1471-2148-5-57

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