Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs

doi:10.1186/1471-2148-4-39

BMC Evolutionary Biology

Volume 4

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Research article

Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs

James R Brown¹ , Kristin K Koretke¹ , Marian L Birkeland¹ , Philippe Sanseau¹ and Denis R Patrick²

¹Bioinformatics Division, Genetics Research, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, P.O. Box 5089, Collegeville Pennsylvania 19426-0989, USA

²Dept. of Molecular Oncology, Microbial, Musculoskeletal and Proliferative Disease Center for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, P.O. Box 5089, Collegeville Pennsylvania 19426-0989, USA

author email corresponding author email

BMC Evolutionary Biology 2004, 4:39doi:10.1186/1471-2148-4-39


Published:	12 October 2004

Additional files

Additional File 1:

Multiple sequence alignment of edited Aurora and Plk4 kinases used to produce the phylogeny shown in Fig. 2.

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Additional File 2:

Accession numbers (gi), Locus link Ids (LID) or genome predicted protein Ids for Aurora and PLK kinases as labelled in the Supplementary Data multiple sequence alignment file S1.

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