Table 5

χ2 testa of the functional distributionb of eukaryotic orthologs (duplicates versus singletons)

Human – Mouse

Dup Obs-Exp

Dup (Obs-Exp)2/Exp

Sing Obs-Exp

Sing (Obs-Exp)2/Exp


Information storage and processing

-49.5

1.46

49.5

9.76

Cellular processes and signaling

241.1

14.39

-241.1

96.04

Metabolism

-11.9

0.09

11.9

0.58

Poorly characterized

-179.6

13.04

179.6

87.07

χ2 P

222.43 6.0 × 10-48

Drosophila Anopheles

Dup Obs-Exp

Dup (Obs-Exp)2/Exp

Sing Obs-Exp

Sing (Obs-Exp)2/Exp

Information storage and processing

-93

9.75

93

26.48

Cellular processes and signaling

124.8

9.29

-124.8

25.25

Metabolism

89.1

8.78

-89.1

23.86

Poorly characterized

-120.9

12.69

120.9

34.46

χ2 P

150.56 2.0 × 10-32

S. cerevisiae C. albicans

Dup Obs-Exp

Dup (Obs-Exp)2/Exp

Sing Obs-Exp

Sing (Obs-Exp)2/Exp

Information storage and processing

-38.6

3.50

38.6

3.63

Cellular processes and signaling

55.4

5.68

-55.4

5.89

Metabolism

36.1

3.39

-36.1

3.52

Poorly characterized

-52.9

9.19

52.9

9.53

χ2 P

44.33 1.3 × 10-9


a Test compares the observed (obs) numbers of proteins in each functional category for duplicates (dup) versus singletons (sing) with the expected (exp) numbers that are calculated based on the relative frequencies of all proteins in each functional category b Functional classifications of proteins were taken from the Clusters of Orthologous Groups database

Jordan et al. BMC Evolutionary Biology 2004 4:22   doi:10.1186/1471-2148-4-22

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