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Evolutionary distance (substitution level) comparisons between duplicates and singletons |
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| Comparisona |
% differenceb |
Duplicate – nc |
Singleton – nc |
Pd |
|
|
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| Human – Mouse (gamma) |
47.11 |
10,753 |
2,517 |
4.2 × 10-50 |
| Human – Mouse (dN/dS) |
37.79 |
10,753 |
2,517 |
5.1 × 10-61 |
| Drosophila – Anopheles (gamma) |
26.37 |
4,902 |
2,233 |
4.8 × 10-50 |
| S. cerevisiae – C. albicans (gamma) |
25.68 |
1,584 |
1,845 |
8.8 × 10-46 |
| E. coli – Y. pestis (gamma) |
5.11 |
1,110 |
1,235 |
0.17 |
| B. subtilis – B. halodurans (gamma) |
4.41 |
1,021 |
1,081 |
0.10 |
| P. horikoshii – P. furiosis (gamma) |
13.38 |
574 |
872 |
0.02 |
|
a Species comparison used to calculate evolutionary distances. Gamma distances are the number of amino acid substitutions per site. dN/dS is the ratio of non-synonymous (dN) to synonymous (dS) nucleotide CDS substitutions. b Percent difference is calculated by taking the absolute value of difference between duplicate and singleton distances and dividing by the average distance for all genes c Numbers of orthologous gene pairs compared to calculate average distances for duplicate and singleton genes d P-value for the t-test comparing duplicate and singleton distance averages | ||||
Jordan et al. BMC Evolutionary Biology 2004 4:22 doi:10.1186/1471-2148-4-22 |
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