Duplicated genes evolve slower than singletons despite the initial rate increase
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* Corresponding author: Eugene V Koonin koonin@ncbi.nlm.nih.gov
BMC Evolutionary Biology 2004, 4:22 doi:10.1186/1471-2148-4-22
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BioMed Central: 13 citations
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Interrogation of alternative splicing events in duplicated genes during evolution Ting-Wen Chen, Timothy H Wu, Wailap V Ng, Wen-Chang Lin BMC Genomics 2011, 12(Suppl 3):S16 (30 November 2011) |
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Evolutionary analysis of the highly dynamic CHEK2 duplicon in anthropoids Claudia Münch, Stefan Kirsch, António MG Fernandes, Werner Schempp BMC Evolutionary Biology 2008, 8:269 (2 October 2008) |
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Tomàs Marques-Bonet, Ze Cheng, Xinwei She, Evan E Eichler, Arcadi Navarro BMC Genomics 2008, 9:384 (12 August 2008) |
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Duplicate gene evolution and expression in the wake of vertebrate allopolyploidization Frédéric JJ Chain, Dora Ilieva, Ben J Evans BMC Evolutionary Biology 2008, 8:43 (8 February 2008) In frog species that have undergone allopolyploidization, gene expression levels of duplicate genes often diverge quickly in spite of strong initial purifying selection, giving insight in to the evolutionary mechanisms that occur after genome duplication in vertebrates.
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Research
All duplicates are not equal: the difference between small-scale and genome duplication Luke Hakes, John W Pinney, Simon C Lovell, Stephen G Oliver, David L Robertson Genome Biology 2007, 8:R209 (4 October 2007) The comparison of pairs of gene duplications generated by small-scale duplications with those created by large-scale duplications shows that they differ in quantifiable ways. It is suggested that this is directly due to biases on the paths to gene retention rather than association with different functional categories. |
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Ian Armstead, Lin Huang, Julie King, Helen Ougham, Howard Thomas, Ian King BMC Genomics 2007, 8:283 (20 August 2007) |
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Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis Uffe Hellsten, Mustafa K Khokha, Timothy C Grammer, Richard M Harland, Paul Richardson, Daniel S Rokhsar BMC Biology 2007, 5:31 (25 July 2007) A doubling of the Xenopus laevis genome accelerated the evolution of over 2,000 gene pairs, and many of these duplicate pairs have substantially different expression levels and patterns corresponding to partially divergent roles or subfunctions.
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Research article
Fast rate of evolution in alternatively spliced coding regions of mammalian genes Ekaterina O Ermakova, Ramil N Nurtdinov, Mikhail S Gelfand BMC Genomics 2006, 7:84 (18 April 2006) A comparison of orthologous human and mouse genes indicates that alternatively spliced exons tend to have a faster rate of evolution than constitutive exons, with the rate of both synonymous and nonsynonymous substitutions increased.
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Etienne GJ Danchin, Philippe Gouret, Pierre Pontarotti BMC Evolutionary Biology 2006, 6:5 (18 January 2006) The absence of certain gene families that are conserved throughout other eukaryotes suggests that the human genome, which is generally considered to have evolved to high levels of complexity, has also undergone simplification and specific gene loss.
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Software
Philippe Gouret, Vérane Vitiello, Nathalie Balandraud, André Gilles, Pierre Pontarotti, Etienne GJ Danchin BMC Bioinformatics 2005, 6:198 (5 August 2005) |
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Georgy P Karev, Yuri I Wolf, Faina S Berezovskaya, Eugene V Koonin BMC Evolutionary Biology 2004, 4:32 (9 September 2004) |