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 CorrectionCorrection: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowlyI King Jordan National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
BMC Evolutionary Biology 2003, 3:5doi:10.1186/1471-2148-3-5 The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2148/3/5
© 2003 Jordan et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. CorrectionAfter the publication of this work [1], we became aware of the fact that the Saccharomyces cerevisiae physical interaction table from the MIPS database that was used to count the number of protein-protein interactions per S. cerevisiae protein contains numerous redundant entries http://mips.gsf.de/proj/yeast/tables/interaction/physical_interact.html webcite. These redundancies were not removed initially, and as a result the numbers of protein-protein interactions reported for S. cerevisiae proteins and compared to the proteins' evolutionary rates were artifactually high. These redundancies have now been removed and the data has been re-analyzed. Here we briefly present the results of the re-analysis with the corrected data sets along with revisions of the relevant tables and figures. Removal of redundant entries resulted in a substantial decrease in the number of protein-protein interactions per S. cerevisiae protein (Figure 1). However, consideration of this revised data with respect to evolutionary rates does not result in any qualitative change in the results or conclusions of our previous report. A total of 2,807 pairs of orthologous proteins, one from S. cerevisiae and one from S. pombe, were identified, and for 1,061 of these, there was data on protein-protein interactions of the S. cerevisiae member in the corrected MIPS data. There appears to be no simple dependence between protein evolution rate and the number of protein-protein interactions; in fact, the slight negative correlation between the number of interactions and the evolutionary rates is no longer statistically significant with the corrected data (Figure 1 and Table 1). There is no significant correlation between the taxonomic distribution of S. cerevisiae orthologs and the number of protein-protein interactions (r2 = 0.0004, p = 0.5). The apparent trend whereby the most prolific S. cerevisiae interactors have, on average, lower evolutionary rates than proteins that are involved in fewer protein-protein interactions also remains (Figure 2 and Table 2).
Table 1. Correlation between the number of protein-protein interactions and the evolutionary rate. Table 2. Statistical significance of the differences in evolutionary rates between groups of proteins with different numbers of interactions. We regret any inconvenience that this inaccuracy in the data used for the original analysis might have caused. We wish to thank Dr. Hunter B. Fraser for bringing this matter to our attention. References
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