Table 1

Inferences from phylogenetic analysis of Runt domain sequences*

NEIGHBOR

PROML

PROTPARS

MRBAYES

Monophyly of deuterostome homologues?

Yes (71 % bootstrap support for the deepest branch)

Yes

Yes for vertebrates and urochordates (74%), ambiguous for echinoderms

Yes (93 % posterior probability)

Runx3 basal in vertebrates?

No

No

No

No

Deepest deuterostome branch is a single-copy gene?

Yes

Yes

Yes

Yes

Deepest protostome branch is a single-copy gene?

Unclear (unresolved topology of the nematode and spider paralogues)

Unclear (unresolved topology of the nematode and spider paralogues)

Unclear (unresolved topology of the nematode and spider paralogues)

Unclear (unresolved topology of the nematode and spider paralogues)

*Inferences from trees constructed using neighbour-joining (NEIGHBOR), maximum likelihood (PROML), maximum parsimony (PROTPARS), and Bayesian inference of phylogeny (MRBAYES) algorithms, as described in Methods. The PROML and PROMLK programs produced identical results.

Rennert et al. BMC Evolutionary Biology 2003 3:4   doi:10.1186/1471-2148-3-4