Figure 4.

Diagram of correlations between number of protein-protein interactions, evolutionary rates, and fitness effects (a) Each arrow represents the correlation between the two variables it connects. Whether or not the correlation is statistically significant by Kendall's Partial Tau is shown by the P-values next to each arrow in (b) and (c). (b) The significance of each correlation for the S. cerevisiae-S. pombe comparison. Note that the arrow connecting number of protein-protein interactions and evolutionary rates is highly significant, with none of the 10⁵ randomizations of the data having a stronger correlation. (c) The significance of each correlation for the S. cerevisiae–C. albicans comparison. Note that the arrow connecting number of protein-protein interactions and evolutionary rates is highly significant, with none of the 10⁵ randomizations of the data having a stronger correlation.