Figure 5.

Phylogenetic analysis of sponge TRP genes. a. Evolutionary relationships of sponge TRP Type I and II genes, values in the nodes indicate Boostrap Support and Posterior Probabilities (see Methods); sponge sequences are in bold. b. Domain diagrams showing the PKD channel domain, transmembrane domain (TM), EF hand domain, and ion transport domains for the pkd2 genes from mouse, Mus musculus; Cca, Corticium candelabrum (Homoscleromorpha); Cel, Caenorhabditis elegans; Sla, Spongilla lacustris (Demospongiae); Sco; Sycon coactum (Calcarea); Ava, Aphrocallistes vastus (Hexactinellida); Cre, Chlamydomonas reinhardtii, and 3D models of the proteins from mouse, Corticium, Sycon, and Chlamydomonas. c. Alignment of bilaterian, cnidarian and sponge TRP sequences showing the TRP domain and TRPbox (Hsap, Homo sapiens; Mmus, Mus musculus; Spur, Strongylocentrotus purpuratus; Cint, Ciona intestinalis, Sko, Saccoglossus kowaleskii, Lforb, Loligo forbesi, Bflo, Branchiostoma floridae, Sman, Schistosoma mansoni, Nvec, Nematostella vectensis). For the full tree and alignment see Additional file 1: Figures S2-S4.

Ludeman et al. BMC Evolutionary Biology 2014 14:3   doi:10.1186/1471-2148-14-3
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