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Open Access Highly Accessed Research article

Genetic and environmental factors affecting cryptic variations in gene regulatory networks

Watal M Iwasaki1*, Masaki E Tsuda2 and Masakado Kawata1

Author Affiliations

1 Department of Ecology and Evolution, Graduate School of Life Sciences, Tohoku University, Sendai 980–8578, Japan

2 , RIKEN Advanced Science Institute, 2-1 Wako, Saitama 351-0198, Japan

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BMC Evolutionary Biology 2013, 13:91  doi:10.1186/1471-2148-13-91

Published: 26 April 2013

Additional files

Additional file 1:

Table S1. Statistics for nested model comparisons. Model selection statistics for the effects of GRN features on the number of cryptic genetic variations in a population. Among all possible combinations, only the models for which the AIC values differed from that of the null model by ≥2 are shown. Note that all these models include the weighted size of the GRN (Eweighted) as an explanatory variable.

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Additional file 2:

Table S2. The effects of each parameter on the evolution of GRNs. The effects of population size (N), mutation rate (μ), number of genes (Vgenome), number of cis-elements (L), positive edge bias (A), strength of selection (S), and number of environments (H) on network properties are shown. The α levels were adjusted to control for multiple comparisons using the false discovery rate (FDR) procedure.

Format: XLS Size: 35KB Download file

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