Open Access Highly Accessed Research article

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

Susan Costantini1*, Ankush Sharma2, Raffaele Raucci2, Maria Costantini3, Ida Autiero2 and Giovanni Colonna24*

Author Affiliations

1 “Pascale Foundation” National Cancer Institute - Cancer Research Center (CROM), via Ammiraglio Bianco, 83013, Mercogliano, Italy

2 Doctorate in Computational Biology, Second University of Naples, Naples, Italy

3 Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy

4 Department of Biochemistry, Biophysics, and General Pathology, Second University of Naples, via Costantinopoli 16, 80138, Naples, Italy

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BMC Evolutionary Biology 2013, 13:60  doi:10.1186/1471-2148-13-60

Published: 5 March 2013

Additional files

Additional file 1: Table S3:

Chromosomal bands as defined by isochore hybridization.

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Additional file 2: Table S1:

Sequence Analysis of Amino Terminal Segments (A) and Carboxy terminal segments (B) where the disordered structure predictions are evidenced in yellow, the NES (Nuclear Export signal) in red and NLS (Nuclear Localization Signal) inviolet. Amino Terminal Segments (C) and Carboxy terminal segments (D) where negative sequence stretchs are evidenced in red, positive sequence stretchs in light blue and predicted phosphorylation site in green.

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Additional file 3: Table S2:

Frequency of amino acids in DisProt and PDB25 datasets collecting disordered and ordered protein domains, respectively.

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