Table 1

Non-synonymous mutations in the rpoB gene conferring rifampicin resistance
High temperature adapted clones Nucleotide change Amino acid change Mutation change Codon change Phenotype (MIC in Rifampicin) Level of rifampicin resistance
56
    A
TC → 
    T
TC
Ile (I) → Phe (F) A1714T I572F 800 μg/mL VERY HIGH
61
    A
TC → 
    T
TC
Ile (I) → Phe (F) A1714T I572F 800 μg/mL
27
    A
TC → 
    C
TC
Ile (I) → Leu (L) A1714C I572L 100 μg/mL HIGH
35
    A
TC → 
    C
TC
Ile (I) → Leu (L) A1714C I572L 100 μg/mL
92
    A
TC → 
    C
TC
Ile (I) → Leu (L) A1714C I572L 100 μg/mL
97
    A
TC → 
    C
TC
Ile (I) → Leu (L) A1714C I572L 100 μg/mL
142
    A
TC → 
    C
TC
Ile (I) → Leu (L) A1714C I572L 100 μg/mL
4 A
    T
C → A
    A
C
Ile (I) → Asn (N) T1715A I572N 50 μg/mL INTERMEDIATE
43 A
    T
C → A
    A
C
Ile (I) → Asn (N) T1715A I572N 25 μg/mL
77 A
    T
C → A
    A
C
Ile (I) → Asn (N) T1715A I572N 25 μg/mL
112 A
    T
C → A
    A
C
Ile (I) → Asn (N) T1715A I572N 50 μg/mL
131 A
    T
C → A
    A
C
Ile (I) → Asn (N) T1715A I572N 25 μg/mL
59 C
    G
T → C
    T
T
Arg (R) → Leu (L) G428T R143L 25 μg/mL

Rodríguez-Verdugo et al.

Rodríguez-Verdugo et al. BMC Evolutionary Biology 2013 13:50   doi:10.1186/1471-2148-13-50

Open Data